UMOD Genotype and Determinants of Urinary Uromodulin in African Populations.

ABSTRACT:

Introduction

Single-nucleotide polymorphisms (SNPs) in the UMOD -PDILT genetic locus are associated with chronic kidney disease (CKD) in European populations, through their effect on urinary uromodulin (uUMOD) levels. The genetic and nongenetic factors associated with uUMOD in African populations remain unknown.

Methods

Clinical parameters, 3 selected UMOD-PDILT SNPs and uUMOD levels were obtained in 1202 young Black and White adults from the African-PREDICT study and 1943 middle aged Black adults from the PURE-NWP-SA study, 2 cross-sectional, observational studies.

Results

Absolute uUMOD and uUMOD/creatinine levels were lower in Black participants compared to White participants. The prime CKD-risk allele at rs12917707 was more prevalent in Black

SUBMITTER: Strauss-Kruger M 

PROVIDER: S-EPMC11652103 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature