Neuronal activity inhibits mitochondrial transport only in synaptically connected segments of the axon.

ABSTRACT: Due to their large scale and uniquely branched architecture, neurons critically rely on active transport of mitochondria in order to match energy production and calcium buffering to local demand. Consequently, defective mitochondrial trafficking is implicated in various neurological and neurodegenerative diseases. A key signal regulating mitochondrial transport is intracellular calcium. Elevated Ca²⁺ levels have been demonstrated to inhibit mitochondrial transport in many cell types, including neurons. However, it is currently unclear to what extent calcium-signaling regulates axonal mitochondrial transport during realistic neuronal activity patterns. We created a robust pipeline to quantify with high spatial resolution, absolute Ca²⁺ concentrations. This allows us to

SUBMITTER: Venneman T 

PROVIDER: S-EPMC11652138 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature