Modeling and optimization of culture media for recombinant Helicobacter pylori vaccine antigen HpaA.

ABSTRACT:

Introduction

H. pylori (Helicobacter pylori) infection represents a significant global health concern, exacerbated by the emergence of drug-resistant strains resulting from conventional antibiotic treatments. Consequently, the development of vaccines with both preventive and therapeutic properties has become crucial in addressing H. pylori infections. The H. pylori adhesin protein HpaA has demonstrated strong immunogenicity across various adjuvants and dosage forms, positioning it as a key candidate antigen for recombinant subunit vaccines against H. pylori. Optimizing fermentation culture conditions is an effective strategy to enhance product yield and lower production costs. However, to date, there has been no systematic investigation into metho

SUBMITTER: Tan R 

PROVIDER: S-EPMC11652157 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature