The potential mechanisms underlying phthalate-induced hypospadias: a systematic review of rodent model studies.

ABSTRACT:

Objectives

Maternal exposure to environmental endocrine disruptors, such as phthalates, during pregnancy is a significant risk factor for the development of hypospadias. By consolidating existing research on the mechanisms by which phthalates induce hypospadias in rodent models, this systematic review aims to organize and analyze the discovered mechanisms and their potential connections.

Methods

The study involved all articles that explored the mechanisms of phthalate-induced hypospadias using rodent models. A comprehensive search of the PubMed and Web of Science databases was conducted using the terms "hypospadias" and "phthalates" before January 20, 2024. Then, two investigators screened for studies worthy of inclusion by setting inclusion and exclusion criteria.

Result

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11652206 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature