Boys With Duchenne Muscular Dystrophy Have Diastolic Dysfunction Based on CMR.

ABSTRACT:

Background

Cardiomyopathy is the leading cause of death in boys with Duchenne muscular dystrophy (DMD). While cardiac magnetic resonance (CMR) is routinely used to assess fibrosis and left ventricular (LV) ejection fraction, CMR measures of LV filling and ejection in DMD have not been reported.

Methods

Patients with DMD (n=179) and healthy controls (n=96) were prospectively enrolled and underwent CMR. The DMD cohort was followed clinically at multiple institutions, and clinical data were recorded. Standard volumes and functions were calculated, and LV filling and ejection curves were measured from baseline CMR. Multivariable linear regressions were used to compare ventricular filling and ejection measures between groups, adjusting for baseline differences. Cox regressions we

SUBMITTER: Starnes JR 

PROVIDER: S-EPMC11652209 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature