Renal and Vascular Functional Decline in Aged Low Birth Weight Murine Adults.

ABSTRACT:

Introduction

Maternal undernutrition (MUN)-induced low birth weight (LBW) neonates are susceptible to the development of high blood pressure and kidney disease later in life, although the underlying pathological causes remain unclear. The study here investigated the role of renal oxidative stress, impairment of vascular function, and altered sensitivity to angiotensin II (Ang II) as factors that contribute to these pathologies in aged LBW mice.

Methods

LBW offspring were generated using a combined protein and caloric restricted MUN mouse model. The resulting LBW offspring were examined 1 year after birth for mean arterial blood pressure (MABP) (carotid artery catheterization), renal blood flow (RBF) (laser Doppler flowmetry), glomerular filtration rate (GFR) (sinistrin clear

SUBMITTER: Rabadi MM 

PROVIDER: S-EPMC11652227 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature