Radially patterned morphogenesis of murine hair follicle placodes ensures robust epithelial budding.

ABSTRACT: The bending of simple cellular sheets into complex three-dimensional (3D) forms requires developmental patterning cues to specify where deformations occur, but how positional information directs morphological change is poorly understood. Here, we investigate how morphogen signaling and cell fate diversification contribute to the morphogenesis of murine hair placodes, in which collective cell movements transform radially symmetric primordia into bilaterally symmetric tubes. Through live imaging and 3D volumetric reconstructions, we demonstrate that Wnt and Shh establish radial patterns of cell fate, cell morphology, and movement within developing placodes. Cell fate diversity at different radial positions provides unique and essential contributions to placode morphogenesis. Further, we show

SUBMITTER: Leybova L 

PROVIDER: S-EPMC11652239 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature