Regulation of Skeletal Muscle Resistance Arteriolar Tone: Temporal Variability in Vascular Responses.

ABSTRACT:

Introduction

A full understanding of the integration of the mechanisms of vascular tone regulation requires an interrogation of the temporal behavior of arterioles across vasoactive challenges. Building on previous work, the purpose of the present study was to start to interrogate the temporal nature of arteriolar tone regulation with physiological stimuli.

Methods

We determined the response rate of ex vivo proximal and in situ distal resistance arterioles when challenged by one-, two-, and three-parameter combinations of five major physiological stimuli (norepinephrine, intravascular pressure, oxygen, adenosine [metabolism], and intralumenal flow). Predictive machine learning models determined which factors were most influential in controlling the rate of arteriolar respons

SUBMITTER: Halvorson BD 

PROVIDER: S-EPMC11652243 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature