Histological and photoacoustic evaluation of rectal cancer after neoadjuvant therapy using microvascular density.

ABSTRACT:

Aim

As non-operative management of rectal cancer proliferates, re-staging and surveillance methods are critical in selecting appropriate patients for organ preservation versus proctectomy. In previous work, the authors have shown that transrectal acoustic resolution photoacoustic microscopy (ARPAM) co-registered with ultrasound can differentiate residual cancer from complete tumoural response to neoadjuvant therapy. We hypothesize that these findings are due to changes in microvascular density (MVD).

Methods

Patients with rectal adenocarcinoma who underwent neoadjuvant therapy, transrectal photoacoustic imaging and resection were included. We first compared immunohistochemical staining with erythroblast transformation-specific-related gene (ERG) immunostain to standard CD31

SUBMITTER: Eltahir AA 

PROVIDER: S-EPMC11652245 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature