Role of ryanodine receptor cooperativity in Ca²⁺-wave-mediated triggered activity in cardiomyocytes.

ABSTRACT: Ca²⁺ waves are known to trigger delayed after-depolarizations that can cause malignant cardiac arrhythmias. However, modelling Ca²⁺ waves using physiologically realistic models has remained a major challenge. Existing models with low Ca²⁺ sensitivity of ryanodine receptors (RyRs) necessitate large release currents, leading to an unrealistically large Ca²⁺ transient amplitude incompatible with the experimental observations. Consequently, current physiologically detailed models of delayed after-depolarizations resort to unrealistic cell architectures to produce Ca²⁺ waves with a normal Ca²⁺ transient amplitude. Here, we address these challenges by incorporating RyR cooperativity into a physiologically detailed model with a rea

SUBMITTER: Zhong M 

PROVIDER: S-EPMC11652246 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature