Predictors of a relapsing course in myelin oligodendrocyte glycoprotein antibody-associated disease.

ABSTRACT:

Background

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently described demyelinating disorder, and children represent about 50% of all cases. Almost half of the patients experience relapses, but very few studies have evaluated predictors of relapse risk, challenging clinical management. The study aimed to identify predictors at MOGAD onset that are associated with a relapsing course.

Methods

Prospectively collected data from paediatric patients with MOGAD seen by the US Network of Paediatric MS Centres were leveraged. Univariable and adjusted multivariable models were used to predict recurrent disease.

Results

We identified 326 MOGAD cases (mean age at first event 8.9 years [SD 4.3], 57% female, 77% white and 74% non-Hispanic) and 4

SUBMITTER: Virupakshaiah A 

PROVIDER: S-EPMC11652255 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature