Deciphering the evolving niche interactome of human hematopoietic stem cells from ontogeny to aging.

ABSTRACT: Hematopoietic stem cells (HSC) reside within specialized microenvironments that undergo dynamic changes throughout development and aging to support HSC function. However, the evolving cell-cell communication networks within these niches remain largely unexplored. This study integrates single-cell RNA sequencing datasets to systematically characterize the HSC niche interactome from ontogeny to aging. We reconstructed single-cell atlases of HSC niches at different developmental stages, revealing stage-specific cellular compositions and interactions targeting HSC. During HSC maturation, our analysis identified distinct patterns of ligand-receptor interactions and signaling pathways that govern HSC emergence, expansion, and maintenance. HSC aging was accompanied by a decrease in supportive nic

SUBMITTER: Feng C 

PROVIDER: S-EPMC11652281 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature