Alternative splicing regulation by tumor suppressing subtransferable candidate 4: a pathway to tumor suppression.

ABSTRACT:

Introduction

RNA splicing is a crucial posttranscriptional process that governs gene expression, and defects in alternative splicing contribute to various diseases, including cancer. Tumor suppressing subtransferable candidate 4 (TSSC4) is a known tumor suppressor and has been identified as part of the U5 small nuclear ribonucleoprotein (snRNP), which is involved in tri-snRNP biogenesis. However, the precise role of TSSC4 in regulating alternative splicing and its impact on tumor growth remain unclear.

Methods

To explore the link between splicing modulation and tumor suppression driven by TSSC4, we conducted transcriptome sequencing (RNA-seq) on TSSC4-knockout and wild-type HeLa cells. Additionally, we analyzed alternative splicing and gene expression in various cancer cell

SUBMITTER: Zhao H 

PROVIDER: S-EPMC11652373 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature