Development of amphiphilic self-assembled nucleolipid as BBB targeting probe based on SPECT.

ABSTRACT: Several approaches have been utilised to deliver therapeutic nanoparticles inside the brain but rendered by certain limitation such as active efflux, non-stability, toxicity of the nanocarrier, transport, physicochemical properties and many more. In this context use of biocompatible nano carriers is currently investigated. We herein present the hypothesis that the nucleoside-lipid based conjugates (nucleolipids) which are biocompatible in nature and have molecular recognition can be tuned for improved permeation across blood-brain barrier (BBB). In this work, a di-C15-palmitoyl-ketal nucleolipid nanoparticle bearing an acyclic chelator has been formulated, radiolabeled with ^99mTc and evaluated for in vivo fate using SPECT imaging. The mean particle size of particles was 113 nm a

SUBMITTER: Tiwari S 

PROVIDER: S-EPMC11652433 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature