MiR-198 targets TOPORS: implications for oral squamous cell carcinoma pathogenesis.

ABSTRACT:

Background

miRNAs play a critical role in the progression of various diseases, including oral squamous cell carcinoma (OSCC), which represents a major health concern and is one of the leading causes for new cancer cases worldwide. The miRNA dysregulation causes havoc and could be attributed to various factors, with epigenetic silencing of tumor suppressor genes being a major contributor to tumorigenesis. In this study, we have explored the tumor suppressive role of miR-198 in OSCC.

Methods

The tumor suppressive effect of miR-198 is established using miRNA analysis in OSCC cell lines, patient samples and xenograft nude mice model. The relationship between the miR-198 and TOPORS is explored using bioinformatics analyses, qRT-PCR, dual-luciferase reporter assay, Western

SUBMITTER: Kaushik P 

PROVIDER: S-EPMC11652479 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature