Myosteatosis in multiple myeloma: a key determinant of survival beyond sarcopenia.

ABSTRACT:

Objective

Fatty infiltration of skeletal muscle (Myosteatosis) is associated with increased frailty, decreased muscle and mobility function, which seems fairly prevalent in multiple myeloma (MM) patients. This study aimed to determine the prognostic value of myosteatosis assessed by CT for progression-free survival (PFS) and overall survival (OS).

Materials and methods

This IRB-approved cohort study included patients with newly diagnosed MM who were treated at a single university hospital and received CT at baseline. Geriatric assessment was performed via International Myeloma Working Group frailty score and Revised Myeloma Comorbidity Index. Myosteatosis was determined through measurement of paravertebral muscle radiodensity. Statistical analyses included uni- and multivari

SUBMITTER: Diallo TD 

PROVIDER: S-EPMC11652573 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature