Differential timing of mitochondrial activation in rat dorsal striatum induced by procedural learning and swimming.

ABSTRACT: Stressful experiences form stronger memories due to enhanced neural plasticity mechanisms linked to glucocorticoid hormones (cortisol in humans, corticosterone in rats). Among other neural structures, the dorsal striatum plays a role in the corticosterone-induced consolidation of stressful memories, particularly in the cued water maze task. Neural plasticity is related to mitochondrial activity due to the relevance of energy production and signaling mechanisms for functional and morphological neuronal adaptations. Corticosterone has been shown to enhance brain mitochondrial activity by activating glucocorticoid receptors. In this context, striatum functions are susceptible to change in relation to mitochondrial responses. Based on this evidence, we hypothesized that training in the cued wa

SUBMITTER: Pegueros-Maldonado R 

PROVIDER: S-EPMC11652596 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature