Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development.

ABSTRACT: Unfit cells with defective signalling or gene expression are eliminated through competition with neighbouring cells. However, physiological roles and mechanisms of cell competition in vertebrates remain unclear. In addition, universal mechanisms regulating diverse cell competition are unknown. Using zebrafish imaging, we reveal that cell competition ensures robust patterning of the spinal cord and muscle through elimination of cells with unfit sonic hedgehog activity, driven by cadherin-mediated communication between unfit and neighbouring fit cells and subsequent activation of the Smad-Foxo3-reactive oxygen species axis. We identify Foxo3 as a common marker of loser cells in various types of cell competition in zebrafish and mice. Foxo3-mediated physiological cell competition is required

SUBMITTER: Matsumoto K 

PROVIDER: S-EPMC11652645 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature