Adipocyte heterogeneity and tumor infiltration of adipose tissue in patients with metastatic breast cancer.

ABSTRACT:

Background

The adipose tissue may serve as a source of energy supporting cancer growth and metastasis. Our understanding of the adipocytes which compose the adipose tissue in different anatomical locations of the body as well as potential microscopic tumor infiltration in patients with metastatic breast cancer remains limited. This study therefore investigates regional variations in adipocyte size and adipose tissue tumor infiltration in patients with metastatic breast cancer.

Methods

Within the UPTIDER rapid autopsy program, (NCT04531696), 94 adipose tissue samples from subcutaneous, visceral, retroperitoneal, and mammary depots of 22 patients with metastatic breast cancer were collected and analyzed. Distant adipocyte size was quantified using digital pathology, and tumor

SUBMITTER: Izci H 

PROVIDER: S-EPMC11652757 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature