Social determinants of health affect disease severity among preschool children with sickle cell disease.

ABSTRACT:

Abstract

Individuals with sickle cell disease (SCD) face the burden of managing a lifelong chronic illness, increasing vulnerability to social determinants of health (SDoH). However, how SDoH contributes to health disparities is understudied. We hypothesized that preschool children with SCD living in poor neighborhoods with higher socio-economic distress would experience increased acute care utilization (ACU; described as emergency department visits plus hospitalizations) despite disease-modifying therapy. Participants' home addresses (aged 0-6 years) were mapped using census tract environmental data from the US Department of Agriculture Food Access Research Atlas. In multivariable analyses controlled for sickle genotype and disease-modifying therapies (hydroxyurea and chronic tran

SUBMITTER: Khan H 

PROVIDER: S-EPMC11652775 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature