A User-Driven Framework for Dose Selection in Pregnancy: Proof of Concept for Sertraline.

ABSTRACT: Despite growing knowledge of pregnancy-induced changes in physiology that may alter maternal and fetal pharmacokinetics, evidence-based antenatal doses are lacking for most drugs. Pharmacokinetic modeling and expanding clinical data in pregnancy may support antenatal doses. We aimed to develop and pilot a comprehensive and user-driven Framework for Dose Selection in Pregnancy to support the clinical implementation of a best-evidence antenatal dose for sertraline. After initial development and evaluation by experts, the framework prototype was piloted to formulate an antenatal dosing strategy for sertraline in depression and anxiety disorders. Next, the framework was reviewed and assessed for usability by a multidisciplinary working committee of end-users comprising healthcare practitioners

SUBMITTER: Koldeweij C 

PROVIDER: S-EPMC11652817 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature