MADRS single items differential changes among patients with melancholic and unspecified depression treated with ECT: an exploratory study.

ABSTRACT:

Introduction

Major depressive disorder (MDD) exhibits heterogeneity in treatment response.

Objective

This exploratory analysis aims to evaluate the differential changes in individual items of the MADRS between melancholic MDD (M-MDD) and unspecified MDD (U-MDD) following electroconvulsive therapy (ECT).

Methods

The study included 23 patients with unipolar MDD who received ECT. Patients were classified as M-MDD or U-MDD according to DSM-5 criteria. MADRS scores were assessed at baseline and one-month post-ECT. Differences between subtypes were analyzed using the Wilcoxon test and multiple linear regression.

Results

Among 23 participants receiving ECT for MDD, 10 had M-MDD and 13 had U-MDD. Baseline MADRS items showed significantly higher scores in the M-MDD grou

SUBMITTER: Pozuelo Moyano B 

PROVIDER: S-EPMC11652832 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature