Metabolic effects and clinical outcomes of olanzapine in schizophrenia: A systematic review and meta-analysis.

ABSTRACT:

Objective

To evaluate the metabolic changes of patients with schizophrenia treated with olanzapine and analyze the correlation between the dosage of the drug, the blood concentration and the clinical response, so as to provide a reference for the clinical diagnosis and treatment.

Methods

PubMed, web of science, Cochrane Library, MEDLINE databases were used to search for studies on olanzapine treatment in patients with schizophrenia, to extract changes in body weight, BMI, waist circumference, cholesterol, PANSS (The Positive and Negative Syndrome Scale), SAPS (The Positive Syndrome Scale), SANS (The Negative Syndrome Scale), BPRS (Brief Psychiatric Rating Scale), CGI (Clinical Global Impressions Ratings), and so on for meta-analysis, and to analyze the correlation of medicat

SUBMITTER: Jin W 

PROVIDER: S-EPMC11652841 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature