Interstitial fibrosis and arrhythmic mitral valve prolapse: Unraveling sex-based differences.

ABSTRACT:

Background

Interstitial fibrosis as quantified by cardiovascular magnetic resonance (CMR) has been demonstrated in arrhythmic mitral valve prolapse (AMVP), a condition with known female predominance. Prior studies of interstitial fibrosis in AMVP have only included cases with significant mitral regurgitation (MR) or mitral annular disjunction (MAD), limiting our understanding of alternative arrhythmic mechanisms in mitral valve prolapse (MVP). We sought to evaluate the association between interstitial fibrosis and AMVP, regardless of MAD and without severe MR, while also investigating the contribution of sex to this association.

Methods

We performed research-based contrast CMR in consecutive individuals with MVP between 2019 and 2022. Extracellular volume fraction (ECV%), a

SUBMITTER: Tastet L 

PROVIDER: S-EPMC11652916 | biostudies-literature | 2024 Winter

REPOSITORIES: biostudies-literature