Phytoconstituents of Chloranthus elatior as a potential adjunct in the treatment of anxiety disorders: In vivo and in silico approaches.

ABSTRACT: Traditional plants have played a vital role in civilization and medicine throughout history. Chloranthus elatior, a plant used in South Asian traditional medicine, has various medicinal applications but limited research on its impact on the central nervous system (CNS). This study analyzed the methanolic leaf extract of Chloranthus elatior (MECE) for secondary metabolites and conducted experiments to evaluate the sedative, and anxiolytic effect of MECE on a mice model. To assess anxiolytic effects, elevated plus maze (EPM) and light-dark box (LDB) tests were performed. Sedative effects were explored in open field and hole-cross tests. Additionally, in silico investigations included molecular docking and ADME/T property assessments for 40 secondary metabolites. The phyt

SUBMITTER: Arobi Katha UT 

PROVIDER: S-EPMC11652921 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature