Monosaccharide coating modulate the intracellular trafficking of gold nanoparticles in dendritic cells.

ABSTRACT: Dendritic cells (DCs) have emerged as a promising target for drug delivery and immune modulation due to their pivotal role in initiating the adaptive immune response. Gold nanoparticles (AuNPs) have garnered interest as a platform for targeted drug delivery due to their biocompatibility, low toxicity and precise control over size, morphology and surface functionalization. Our investigation aimed to elucidate the intracellular uptake and trafficking of AuNPs coated with different combinations of monosaccharides (mannose, galactose, and fucose) in DCs. We used 30 unique polymer-tethered monosaccharide combinations to coat 16 nm diameter spherical gold nanoparticles and investigated their effect on DCs phenotype, uptake, and intracellular trafficking. DCs internalized AuNPs coated with 100 %

SUBMITTER: Alobaid MA 

PROVIDER: S-EPMC11652954 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature