Gut microbiota profiling in injection drug users with and without HIV-1 infection in Puerto Rico.

ABSTRACT:

Introduction

The full extent of interactions between human immunodeficiency virus (HIV) infection, injection drug use, and the human microbiome is unclear. In this study, we examined the microbiomes of HIV-positive and HIV-negative individuals, both drug-injecting and non-injecting, to identify bacterial community changes in response to HIV and drug use. We utilized a well-established cohort of people who inject drugs in Puerto Rico, a region with historically high levels of injection drug use and an HIV incidence rate disproportionately associated with drug use.

Methods

Using amplicon-based 16S rDNA sequencing, we identified amplicon sequence variants (ASVs) that demonstrated significant variations in the composition of microbial communities based on HIV status and drug use

SUBMITTER: Aluthge N 

PROVIDER: S-EPMC11652967 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature