Association of mixed polycyclic aromatic hydrocarbons exposure with cardiovascular disease and the mediating role of inflammatory indices in US adults.

ABSTRACT:

Background

Cardiovascular disease (CVD) is the leading cause of death worldwide. Few studies have investigated the effects of mixed polycyclic aromatic hydrocarbon (PAH) exposure on CVD prevalence. We aimed to evaluate the association between mixed PAHs exposure and CVD and determine the extent to which these links are mediated by inflammatory indices.

Methods

We used National Health and Nutrition Examination Survey (NHANES) data from 2003 to 2016. Adults with a diagnosis of CVD and seven monohydroxylated PAH metabolites (OH-PAHs) in their urine samples were included. Multivariate logistic regression and Bayesian kernel machine regression (BKMR) models were used to estimate the association between single and mixed PAHs exposure and CVD. Mediation analysis was used to evaluat

SUBMITTER: Du T 

PROVIDER: S-EPMC11652969 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature