Vascular risk factors are associated with grey matter atrophy in secondary progressive multiple sclerosis.

ABSTRACT:

Background

Comorbidities including vascular risk factors can be associated with whole and regional brain atrophy in multiple sclerosis (MS). This has been examined in mixed MS cohorts in prospective or observational studies; however, the association between vascular comorbidities (VCM) in secondary progressive MS (SPMS) and brain atrophy has been less well studied. The aim was to investigate the cross-sectional and longitudinal association between VCM, comorbidity burden and brain atrophy in SPMS.

Methods

Post hoc analysis of 445 participants from the MS-Secondary Progressive multi-arm trial (MS-SMART)-a multi-arm multicentre phase-2b randomised placebo-controlled trial of three agents in SPMS (NCT01910259). VCM (hypertension, hyperlipidaemia) but also asthma, hypothyroidism

SUBMITTER: John NA 

PROVIDER: S-EPMC11653023 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature