Cerebral white matter myelination is associated with longitudinal changes in processing speed across the adult lifespan.

ABSTRACT: Myelin's role in processing speed is pivotal, as it facilitates efficient neural conduction. Its decline could significantly affect cognitive efficiency during ageing. In this work, myelin content was quantified using our advanced MRI method of myelin water fraction mapping. We examined the relationship between myelin water fraction at the time of MRI and retrospective longitudinal change in processing speed among 121 cognitively unimpaired participants, aged 22-94 years, from the Baltimore Longitudinal Study of Aging and the Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (a mean follow-up duration of 4.3 ± 6.3 years) using linear mixed-effects models, adjusting for demographics. We found that higher myelin water fraction values correlated with longitudinally b

SUBMITTER: Gong Z 

PROVIDER: S-EPMC11653079 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature