Get to know your neighbors with a SNAQ™: A framework for single cell spatial neighborhood analysis in immunohistochemical images.

ABSTRACT: Analyzing the local microenvironment of tumor cells can provide significant insights into their complex interactions with their cellular surroundings, including immune cells. By quantifying the prevalence and distances of certain immune cells in the vicinity of tumor cells through a neighborhood analysis, patterns may emerge that indicate specific associations between cell populations. Such analyses can reveal important aspects of tumor-immune dynamics, which may inform therapeutic strategies. This method enables an in-depth exploration of spatial interactions among different cell types, which is crucial for research in oncology, immunology, and developmental biology. We introduce an R Markdown script called SNAQ™ (Single-cell Spatial Neighborhood Analysis and Q

SUBMITTER: Silver A 

PROVIDER: S-EPMC11653138 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature