DNA-mediated self-assembly oxidative damage amplifier combined with copper and MTH1 inhibitor for cancer therapy.

ABSTRACT: Chemo-dynamic therapy (CDT) has a great potential in tumor extirpation. It entails producing hypertoxic reactive oxygen species (ROS) that damage the DNA of tumor cells and other biomacromolecules. However, the efficiency of CDT is severely hampered by the massive presence of glutathione (GSH) in tumor cells and the interference of ROS defense systems, such as Mutt homolog 1 (MTH1) protein sanitizes ROS-oxidized nucleotide pools. In this research, DNA-mediated self-assembly nanoparticles (HTCG@TA NPs) were engineered with high-performance amplified oxidative damage and gene therapy effect for synergistic anti-tumor treatment. Cu²⁺ was converted into Cu ⁺ by redox reactions to deplete GSH while H₂O₂ was catalyzed to generate hydroxyl radicals (·OH

SUBMITTER: Ren C 

PROVIDER: S-EPMC11653152 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature