Microwave-assisted synthesis of base-modified fluorescent 1,4-dihydropyridine nucleosides: photophysical characterization and insights.

ABSTRACT: A synthesis of a small library of fluorescent 1,4-dihydropyridine nucleoside analogues has been successfully carried out under solvent-free conditions via a one-pot three-component Hantzsch condensation reaction. The process involved a Ba(NO₃)₂ catalyzed solvent-free reaction between 3',5'-di-O-acetyl-5-formyl-2'-deoxyuridine, differently substituted β-keto ester and ammonium acetate under microwave irradiation. This facile methodology yielded the desired products with very high yields (86-96%) under solvent-free reaction conditions in a short reaction time, which was followed by a simple workup. Yields obtained under microwave and conventional heating were compared, with the microwave irradiation condition displaying superior results. The synthesized co

SUBMITTER: Arora A 

PROVIDER: S-EPMC11653174 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature