FTO Facilitates Cervical Cancer Malignancy Through Inducing m6A-Demethylation of PIK3R3 mRNA.

ABSTRACT:

Background

The incidence rate and mortality of cervical cancer rank the fourth in the global female cancer. N6-methyladenosine (m6A) always plays an important role in tumor progression, and fat mass and obesity-associated gene (FTO) works as the m6A demethylase.

Aims

Our study aimed to narrate the biological function and potential mechanisms for FTO in cervical cancer malignancy.

Materials & methods

We analyzed potential clinical value of FTO in cervical cancer patients. The relative protein levels of FTO in cervical cancerous tissue and paracancerous tissue were verified by IHC. After changing the FTO expression level by lentivirus transfection, the proliferation and metastasis ability of cervical cancer cells were detected both in vitro and in vivo. Further, Merip-s

SUBMITTER: Chen B 

PROVIDER: S-EPMC11653219 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature