Disulfide-Bridged Cationic Dinuclear Ir(III) Complex with Aggregation-Induced Emission and Glutathione-Consumption Properties for Elevating Photodynamic Therapy.

ABSTRACT: The ability of photosensitizers (PSs) to generate reactive oxygen species (ROS) is crucial for photodynamic therapy (PDT). However, many traditional PSs face the drawbacks that aggregation-caused quenching (ACQ) and highly expressed glutathione (GSH) in the tumor microenvironment seriously limit their ROS generation ability. Herein, we report two cationic dinuclear iridium complexes, Ir-C-C-Ir and Ir-S-S-Ir, which possess aggregation-induced emission (AIE). Ir-S-S-Ir was constructed for GSH consumption by introducing a disulfide linkage between the two auxiliary ligands with imine units. Quantum chemical calculations revealed that Ir-C-C-Ir and Ir-S-S-Ir possess many degenerate states, which provide more channels for singlet-to-triplet exciton transitions

SUBMITTER: Huang M 

PROVIDER: S-EPMC11653252 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature