Organometallic Half-Sandwich Complexes of 8-Hydroxyquinoline-Derived Mannich Bases with Enhanced Solubility: Targeting Multidrug Resistant Cancer.

ABSTRACT: Drug resistance is a major obstacle in cancer treatment. Herein, four novel organometallic complexes, with the general formula [Ru(η⁶-p-cymene)(HL)Cl]Cl and [Rh(η⁵-C₅Me₅)(HL)Cl]Cl, were developed to target multidrug-resistant (MDR) cancer cells, where HL denotes 8-hydroxyquinoline-derived Mannich bases (HQCl-pyr and HQCl-pip). The aim of the complexation was to obtain compounds with improved drug-like properties. The complexes were comprehensively characterized by various spectroscopic methods in terms of their structure, solution speciation and interaction with human serum albumin. The structure of [Rh(η⁵-C₅Me₅)(HQCl-pip)Cl]Cl was analyzed by X-ray crystallography. The complexes were found to be highly sta

SUBMITTER: Pivarcsik T 

PROVIDER: S-EPMC11653257 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature