Synthetic plasma pool cohort correction for affinity-based proteomics datasets allows multiple study comparison.

ABSTRACT: Proteomics stands as the crucial link between genomics and human diseases. Quantitative proteomics provides detailed insights into protein levels, enabling differentiation between distinct phenotypes. OLINK, a biotechnology company from Uppsala, Sweden, offers a targeted, affinity-based protein measurement method called Target 96, which has become prominent in the field of proteomics. The SCALLOP consortium, for instance, contains data from over 70.000 individuals across 45 independent cohort studies, all sampled by OLINK. However, when independent cohorts want to collaborate and quantitatively compare their target 96 protein values, it is currently advised to include 'identical biological bridging' samples in each sampling run to perform a reference sample normalization, correcting techni

SUBMITTER: Heylen D 

PROVIDER: S-EPMC11653412 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature