Ramelteon exposure and survival of critically Ill sepsis patients: a retrospective study from MIMIC-IV.

ABSTRACT:

Background

The effect of ramelteon, a melatonin receptor agonist, on survival in septic patients remains unknown. The purpose of this retrospective cohort study was to explore the relationship between ramelteon exposure and survival outcomes in septic patients.

Methods

Data from septic patients admitted to the intensive care unit (ICU) were extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, with patients categorized into ramelteon exposure and non-exposure groups based on the use of ramelteon. The primary outcome was 30-day mortality, and secondary outcomes included 90-day mortality, in-hospital mortality, length of ICU stay, and hospital stay. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were emplo

SUBMITTER: Han YY 

PROVIDER: S-EPMC11653545 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature