Treatment with combined exercise in patients with resistant major depression (TRACE-RMD): study protocol for a randomised controlled trial.

ABSTRACT:

Background

Around 40% of people with major depressive disorder (MDD) experience moderate remission, with the remainder meeting the criteria for resistant major depression (RMD). It has been shown that exercise has a low-to-moderate effect on MDD, but there is a lack of evidence on exercise interventions in RMD patients. The primary purpose of the proposed study will be to investigate the effect of a 12-week supervised combined exercise program on depressive symptoms in people with RMD compared to a treatment-as-usual (TAU) group.

Method

This randomised, single-blind, controlled experimental trial will include 70 adults (≥ 18 years old) with RMD. Participants randomised to an exercise intervention, or a TAU group will be assessed at baseline and after a three-month interventi

SUBMITTER: Iriarte-Yoller N 

PROVIDER: S-EPMC11653556 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature