Altered dynamic functional connectivity in antagonistic state in first-episode, drug-naive patients with major depressive disorder.

ABSTRACT:

Objective

Major depressive disorder (MDD) is known to be characterized by disrupted brain functional network connectivity (FNC) patterns, while the dynamic change mode of different functional networks is unclear. This study aimed to characterize specific dynamic alterations pattern on intrinsic FNC in MDD by combining static FNC (sFNC) and dynamic FNC (dFNC).

Methods

A total of 48 first-episode drug-naïve MDD and 48 matched healthy controls (HCs) were included in this study. The sFNC and dFNC were analyzed using complete time-series and sliding window approach, respectively. Both sFNC and dFNC differences between groups were analyzed and associations between disease severity and aberrant FNC were explored.

Results

MDD patients exhibited lower sFNC within and between s

SUBMITTER: Wang M 

PROVIDER: S-EPMC11653573 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature