Striatal Cholinergic Interneurons Control Physical Nicotine Withdrawal via Muscarinic Receptor Signaling.

ABSTRACT: Striatal cholinergic interneurons (ChIs) provide acetylcholine tone to the striatum and govern motor functions. Nicotine withdrawal elicits physical symptoms that dysregulate motor behavior. Here, the role of striatal ChIs in physical nicotine withdrawal is investigated. Mice under RNAi-dependent genetic inhibition of striatal ChIs (ChI^GI) by suppressing the sodium channel subunit Na_V1.1, lessening action potential generation and activity-dependent acetylcholine release is first generated. ChI^GI markedly reduced the somatic signs of nicotine withdrawal without affecting other nicotine-dependent or striatum-associated behaviors. Multielectrode array (MEA) recording revealed that ChI^GI reversed ex vivo nicotine-induced alterations in the number of

SUBMITTER: Kim B 

PROVIDER: S-EPMC11653618 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature