Catalytically Active Ti-Based Nanomaterials for Hydroxyl Radical Mediated Clinical X-Ray Enhancement.

ABSTRACT: Nanoparticle radioenhancement offers a promising strategy for augmenting radiotherapy by locally increasing radiation damage to tumor tissue. While past research has predominantly focused on nanomaterials with high atomic numbers, such as Au and HfO₂, recent work has revealed that their radioenhancement efficacy decreases considerably when using clinically relevant megavoltage X-rays as opposed to the orthovoltage X-rays typically employed in research settings. Here, radiocatalytically active Ti-based nanomaterials for clinical X-ray therapy settings are designed. A range of candidate materials, including TiO₂ (optionally decorated with Ag or Pt nanoseeds), Ti-containing metal-organic frameworks (MOFs), and 2D Ti-based carbides known as Ti₃C₂T

SUBMITTER: Gerken LRH 

PROVIDER: S-EPMC11653640 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature