Bioadhesive hybrid system of niosomes and pH sensitive <i>in situ</i> gel for itraconazole ocular delivery: Dual approach for efficient treatment of fungal infections.

ABSTRACT: Itraconazole (ITZ) is a highly effective antifungal agent. However, its oral application is associated with systemic toxicity and poor topical use. The present study aims to improve the antifungal activity of ITZ by loading it into bioadhesive niosomes. This approach is considered to enhance the ocular permeation of ITZ, thereby boosting its efficacy against fungal infections. Therefore, it was encapsulated into niosomes (F1) and subsequently coated with hyaluronic acid (HA; F2), chitosan (CS; F3), or a bilayer of CS/HA (F4). In addition, they were further incorporated into pH-sensitive in situ gels. This dual approach is expected to increase the amount of corneal-permeated ITZ, facilitating more effective management of ocular fungal infection. Firstly, the niosomes were prepared by

SUBMITTER: Badran MM 

PROVIDER: S-EPMC11653644 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature