Expression of mTOR, CD163, α-SMA, FOXp3 as survival predictors and its significance in patients with oral squamous cell carcinoma.

ABSTRACT:

Background

Oral cancer; categorised under head and neck cancers (HNC) predominantly originates from squamous cells and is referred as oral squamous cell carcinoma (OSCC). Various factors (internal and external) causes OSCC. PI3K/AKT/mTOR pathways are known to be primarily mutated in HNC. mTOR remains as a key regulator for various physiological and developmental processes in normal and cancer cells. Cancer cells are surrounded by tumor microenvironment, majorly composed of immune cells. Cancer associated fibroblasts, macrophages and regulatory T cells controlled by mTOR, plays an important role in the progression of cancer.

Methods

Two hundred sixty retrospective patient samples were collected along with their demographical and clinic-pathological data. Here, we have analyse

SUBMITTER: Ramalingam S 

PROVIDER: S-EPMC11653707 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature