Polygenic Risk of Epilepsy and Poststroke Epilepsy.

ABSTRACT:

Background

Epilepsy is highly heritable, with numerous known genetic risk loci. However, the genetic predisposition's role in poststroke epilepsy (PSE) remains understudied. This study assesses whether a higher genetic predisposition to epilepsy raises poststroke survivor's risk of PSE.

Methods

We conducted a case-control genetic association study nested within the UK Biobank, a large UK-based prospective cohort. Our exposures of interest were 2 distinct polygenic risk scores-generalized and focal epilepsy-modeled as deciles and constructed using genetic variants identified in the latest International League Against Epilepsy genome-wide association study meta-analysis. We aimed to evaluate the association between these polygenic risk scores and their corresponding subtype of

SUBMITTER: Clocchiatti-Tuozzo S 

PROVIDER: S-EPMC11653790 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature