Dose to cardiac substructures and cardiovascular events in esophageal cancer patients treated with definitive radiotherapy.

ABSTRACT:

Introduction

While there is a growing amount of data on the cardiac toxicity of radiotherapy (RT) in relation to its impact on cardiac sub-structures (CSS), there are only few studies addressing this issue in patients followed for esophageal cancer (ESOC). We aimed to evaluate the association between independent parameters of dose received by CSS and major cardiac events (MACEs) in this population.

Materials and methods

We retrospectively analyzed 122 patients treated with exclusive RT or chemo-RT for ESOC. Heart and CSS i.e. right atrium, left atrium (LA), right ventricle, left ventricle and myocardium, have been automatically segmented, and dose volume histogram were extracted. Cardiac events were collected focusing on the occurrence of MACEs of grade 3 or higher (G3+) and

SUBMITTER: Nguyen V 

PROVIDER: S-EPMC11653828 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature