Factors influencing Nirmatrelvir/Ritonavir concentration in patients with COVID-19.

ABSTRACT:

Background

In the filed of antiviral therapy, effective therapeutic concentration is beneficial to shorten the recovery time of patients and reduce the transmission rate.The aim of this study is to retrospectively analyze the factors that lead to the drug concentration of Nirmatrelvir /Ritonavir (NMV/RTV) not reaching the standard.

Methods

In this study, the NMV/RTV drug concentration(Cnmv/rtv) data (n = 114) of COVID-19 patients over 18 years old were collected from May 2022 to July 2022, and the results of the patients were retrospectively compared. According to the analysis of the early study of NMV/RTV, combined with the research results at home and abroad, according to whether the measured drug concentration > 987 ng/ml, the patients were divided into target group and n

SUBMITTER: Xu P 

PROVIDER: S-EPMC11653860 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature