SEC14L2 regulates the transport of cholesterol in non-small cell lung cancer through SCARB1.

ABSTRACT:

Background

Inhibiting cholesterol metabolism has shown great potential in non-small cell lung cancer (NSCLC). However, the regulatory mechanism of the lipid metabolism key factor Sect. 14-like lipid binding 2 (SEC14L2) in NSCLC remains unclear. This study investigates the effects of differentially expressed genes related to cholesterol metabolism on the development of NSCLC.

Methods

Cox regression and survival analysis were performed to screen cholesterol metabolism-related genes and predict survival prognosis in NSCLC patients. The proliferation and migration of NSCLC cells were assessed by CCK-8, EdU, colony formation and wound-healing assay. Cholesterol depletion and rescue trials were used to evaluate the effect of SEC14L2 on cholesterol transport in NSCLC cells. IF and

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC11653909 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature