Effect of antipsychotic on mismatch negativity amplitude and evoked theta power in drug-naive patients with schizophrenia.

ABSTRACT:

Background

Recurrent observations have indicated the presence of deficits in mismatch negativity (MMN) among schizophrenia. There is evidence suggesting a correlation between increased dopaminergic activity and reduced MMN amplitude, but there is no consensus on whether antipsychotic medications can improve MMN deficit in schizophrenia.

Methods

We conducted clinical assessments, cognitive function tests, and EEG data collection and analysis on 31 drug-naïve patients with schizophrenia. Comprehensive evaluation tools such as PANSS and MCCB. MMN amplitude was analyzed by event-related potential (ERP) approaches, evoked theta power was analyzed by event-related spectral perturbation (ERSP) approaches.

Results

Our findings indicate that antipsychotic treatment significant

SUBMITTER: Xiong YB 

PROVIDER: S-EPMC11653912 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature