Characteristics, outcomes and the necessity of continued guideline-directed medical therapy in patients with heart failure with improved ejection fraction.

ABSTRACT:

Background

Much remains to be learned about patients with heart failure with improved ejection fraction (HFimpEF).

Objective

This study sheds light on the characteristics and clinical outcomes of HFimpEF patients, including the consequences of halting guideline-directed medical therapy (GDMT).

Methods

This retrospective study was conducted on patients diagnosed with heart failure with reduced ejection fraction (HFrEF) who underwent a second echocardiogram at least 6 months apart between January 2009 and February 2023. The primary outcomes were major adverse cardiovascular events (MACEs), including all-cause mortality and heart failure hospitalization. The second outcome was recurrent HFrEF.

Results

Of 4,560 HFrEF patients were included, 3,289 (72.1%) achieved H

SUBMITTER: Chen QF 

PROVIDER: S-EPMC11654040 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature